The Pittsburgh Reference Laboratory Alliance:A Model for Laboratory Medicine in the 21st Century

The laboratory notebook in the 21st century

D etailed note-keeping is a prerequisite for, if not a key component of, scientific discovery. An unrecorded experiment is lost to the world even if it sparks a great idea in a scientist’s mind: Additional work is needed to reproduce and confirm the original observation and to test the hypothesis by novel experimental strategies. Hence, a detailed record of the experimental setup, observations,...

The molecular pathology laboratory of the 21st century.

Human cells contain deoxyribonucleic acid in mitochondria and nuclei. Human diseases may be caused by mutations in mitochondrial DNA, nuclear DNA or both. The volume of work performed in the diagnostic molecular pathology laboratory will continue to grow as more disease-related mutations are discovered. Many factors will influence the diagnostic molecular pathology laboratory in the 21st centur...

O2- Gifted Identification in the 21st Century

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Implementation of reference systems in laboratory medicine.

In laboratory medicine, meaningful measurements are essential for the diagnosis, risk assessment, treatment, and follow-up of patients; therefore, methods applied in diagnostic measurements must be accurate, precise, specific, and comparable among laboratories (1 ). A given analytical measurement has only one true result, and the reliability of a measurement lies both in the result obtained and...

The Challenges of Cognitive Neuroscience in the 21st Century